Analysis of the magnetoencephalogram background activity in Alzheimer's disease patients with auto-mutual information

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Author list: Fernández A
Publisher: Elsevier: 12 months
Publication year: 2007
Volume number: 87
Issue number: 3
Start page: 239
End page: 247
Number of pages: 9
ISSN: 0169-2607
Languages: English-Great Britain (EN-GB)


The aim of the present study was to analyse the magnetoencephalogram
(MEG) background activity in patients with Alzheimer's disease (AD), one
of the most frequent disorders among elderly population. For this pilot
study, we recorded the MEGs with a 148-channel whole-head magnetometer
in 20 patients with probable AD and 21 age-matched control subjects.
Artefact-free epochs of 3392 samples were analysed with auto-mutual
information (AMI). Average AMI decline rates were lower for the AD
patients' recordings than for control subjects' ones. Statistically
significant differences were found using a Student's t-test (p <
0.01) in 144 channels. Mean AMI values were analysed with a receiver
operating characteristic curve. Sensitivity, specificity and accuracy
values of 75%, 90.5% and 82.9% were obtained. Our results show that AMI
estimations of the magnetic brain activity are different in both groups,
hence indicating an abnormal type of dynamics associated with AD. This
study suggests that AMI might help medical doctors in the diagnosis of
the disease. © 2007 Elsevier Ireland Ltd. All rights reserved.


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