Development of transplanted fetal bones

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Publication Details

Subtitle: Differences between isografts and allografts in mice
Author list: Sckell A
Publisher: Lippincott, Williams & Wilkins
Publication year: 2001
Issue number: 382
Start page: 267
End page: 276
Number of pages: 10
ISSN: 0009-921X
Languages: English-Great Britain (EN-GB)


Abstract

Allogeneic bone from bone banks frequently is used when large skeletal
defects have to be bridged in orthopaedic surgery. Beside immunologic
rejection of the graft, the loss in osteogenic potential caused by bone
banking procedures may be a major reason for limited clinical success.
Similar problems as described for bone have occurred with cartilage and
osteochondral transplants. Improving the properties of allogenic bone so
that its biologic activity becomes comparable to autologous bone could
be substantially beneficial for the outcome of allograft
transplantation. To dissect the steps involved in the integration of a
fetal osteochondral graft as it matures to bone, the current study
compared the development and biologic function of metatarsals from
18-day-old fetal mice freshly transplanted in three different
immunologic settings. Morphologic assessment of (1) isografts and (2)
allografts in nonsensitized hosts 12 days after transplantation revealed
that the grafts bear an intrinsic potential to develop after
transplantation. In allografts in nonsensitized hosts, however, a slight
alteration in biologic activity as compared with isografts could be
detected already in this early phase after transplantation by in situ
hybridization for messenger ribonucleic acids encoding extracellular
matrix proteins. (3) In contrast to isografts and allografts in
nonsensitized hosts, morphologic features and biologic function of
allografts transplanted to presensitized hosts were altered severely.


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Last updated on 2019-10-08 at 00:15