Effect of humanised anti-L- selectin antibody HuDreg 200 on leukocyte kinetics in pulmonary microcirculation in endotoxinemia | Effekt des humanisierten anti-L-Selektin Antikörpers HuDreg 200 auf die Leukozytenkinetik in der pulmonalen Mikrozirkulation bei Endotoxinämie.

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Author list: Sckell A
Publication year: 1998
Journal: Langenbecks Archiv fur Chirurgie. Supplement. Kongressband. Deutsche Gesellschaft fur Chirurgie. Kongress
Volume number: 115
Issue number: Suppl I
Start page: 709
End page: 711
Number of pages: 3
Languages: English-Great Britain (EN-GB)


Abstract

In the pulmonary circulation, endotoxemia induces leukocyte/endothelium
interaction in pulmonary arterioles and venules. Thus, leukocytes may
contribute to the pathogenesis of acute lung injury. In order to
investigate, whether this interaction can be inhibited by early blockade
of the adhesion cascade, we studied the effect of the humanized
anti-L-selectin antibody HuDreg 200 on leukocyte kinetics in pulmonary
arterioles and venules following i.v.-infusion of endotoxin. In
endotoxemia HuDreg 200 reduces sticking of leukocytes in both pulmonary
arterioles and venules. Thus, we were able to demonstrate that early
blockade of the adhesion cascade effectively prevents leukocyte
accumulation in pulmonary microvessels in endotoxemia. Therefore, HuDreg
200 may exhibit protective effects on the manifestation of
leukocyte-mediated acute lung injury.


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