Effects of isoflurane on regional pulmonary blood flow during one-lung ventilation

Journal article


Research Areas

Publication Details

Author list: Sckell A
Publisher: Elsevier
Publication year: 1995
Volume number: 74
Issue number: 2
Start page: 209
End page: 216
Number of pages: 8
ISSN: 0007-0912
Languages: English-Great Britain (EN-GB)


Isoflurane has been reported to inhibit hypoxic pulmonary
vasoconstriction. However, the effects of one-lung ventilation and
isoflurane on regional pulmonary blood flow (Or) have not been
investigated in detail. Therefore, using radionuclide labelled
microspheres we measured Or in rabbits (n = 8) in the left lateral
decubitus position during two- and one-lung ventilation under i.v,
baseline anaesthesia and during additional administration of 1.5%
isoflurane. Macrohaemodynamic variables were recorded continuously.
Isoflurane increased non-dependent lung blood flow during two-lung
ventilation. One-lung ventilation caused a homogeneous decrease in Or
throughout the hypoxic lung, irrespective of isoflurane administration
(P < 0.001). However, isoflurane significantly augmented Or of the
hypoxic lung during one-lung ventilation (P < 0.05). During all
phases, Or of the upper lobe was higher compared with that in the lower
lobe in isogravitational slices of both lungs; a ventrodorsal perfusion
gradient was found in the left upper robe. We conclude that 1.5%
isoflurane increased perfusion of the non-dependent lung, inhibited
hypoxic pulmonary vasoconstriction-induced redistribution of pulmonary
blood flow and did not influence isogravitational perfusion gradients.


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