Effects of isoflurane on regional pulmonary blood flow during one-lung ventilation

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Auteurs / Editeurs

Domaines de Recherche

Détails sur la publication

Liste des auteurs: Sckell A
Editeur: Elsevier
Année de publication: 1995
Numéro du volume: 74
Numéro de publication: 2
Page d'accueil: 209
Dernière page: 216
Nombre de pages: 8
ISSN: 0007-0912
Languages: Anglais-Royaume-Uni (EN-GB)


Isoflurane has been reported to inhibit hypoxic pulmonary
vasoconstriction. However, the effects of one-lung ventilation and
isoflurane on regional pulmonary blood flow (Or) have not been
investigated in detail. Therefore, using radionuclide labelled
microspheres we measured Or in rabbits (n = 8) in the left lateral
decubitus position during two- and one-lung ventilation under i.v,
baseline anaesthesia and during additional administration of 1.5%
isoflurane. Macrohaemodynamic variables were recorded continuously.
Isoflurane increased non-dependent lung blood flow during two-lung
ventilation. One-lung ventilation caused a homogeneous decrease in Or
throughout the hypoxic lung, irrespective of isoflurane administration
(P < 0.001). However, isoflurane significantly augmented Or of the
hypoxic lung during one-lung ventilation (P < 0.05). During all
phases, Or of the upper lobe was higher compared with that in the lower
lobe in isogravitational slices of both lungs; a ventrodorsal perfusion
gradient was found in the left upper robe. We conclude that 1.5%
isoflurane increased perfusion of the non-dependent lung, inhibited
hypoxic pulmonary vasoconstriction-induced redistribution of pulmonary
blood flow and did not influence isogravitational perfusion gradients.


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