Effects of isoflurane on regional pulmonary blood flow during one-lung ventilation

Zeitschriftenaufsatz


Autoren/Herausgeber


Forschungsfelder


Details zur Publikation

Autorenliste: Sckell A
Verlag: Elsevier
Jahr der Veröffentlichung: 1995
Bandnummer: 74
Heftnummer: 2
Erste Seite: 209
Letzte Seite: 216
Seitenumfang: 8
ISSN: 0007-0912
Sprachen: Englisch-Vereinigtes Königreich (EN-GB)


Beschreibung

Isoflurane has been reported to inhibit hypoxic pulmonary
vasoconstriction. However, the effects of one-lung ventilation and
isoflurane on regional pulmonary blood flow (Or) have not been
investigated in detail. Therefore, using radionuclide labelled
microspheres we measured Or in rabbits (n = 8) in the left lateral
decubitus position during two- and one-lung ventilation under i.v,
baseline anaesthesia and during additional administration of 1.5%
isoflurane. Macrohaemodynamic variables were recorded continuously.
Isoflurane increased non-dependent lung blood flow during two-lung
ventilation. One-lung ventilation caused a homogeneous decrease in Or
throughout the hypoxic lung, irrespective of isoflurane administration
(P < 0.001). However, isoflurane significantly augmented Or of the
hypoxic lung during one-lung ventilation (P < 0.05). During all
phases, Or of the upper lobe was higher compared with that in the lower
lobe in isogravitational slices of both lungs; a ventrodorsal perfusion
gradient was found in the left upper robe. We conclude that 1.5%
isoflurane increased perfusion of the non-dependent lung, inhibited
hypoxic pulmonary vasoconstriction-induced redistribution of pulmonary
blood flow and did not influence isogravitational perfusion gradients.


Schlagwörter

Es wurden keine entsprechenden Inhalte gefunden.


Dokumente

Es wurden keine entsprechenden Inhalte gefunden.

Zuletzt aktualisiert 2019-13-08 um 00:15