A network model for biofilm development in Escherichia coli K-12

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Details zur Publikation

Autorenliste: Shala AA, Restrepo S, Barrios AFG
Verlag: BMC (part of Springer Nature)
Jahr der Veröffentlichung: 2011
Bandnummer: 8
Seitenumfang: 9
ISSN: 1742-4682
Sprachen: Englisch-Vereinigtes Königreich (EN-GB)


Beschreibung

Background: In nature, bacteria often exist as biofilms. Biofilms are communities of microorganisms attached to a surface. It is clear that biofilm grown cells harbor properties remarkably distinct from planktonic cells. Biofilms frequently complicate treatments of infections by protecting bacteria from the immune system, decreasing antibiotic efficacy and dispersing planktonic cells to distant body sites. In this work, we employed enhanced Boolean algebra to model biofilm formation.Results: The network obtained describes biofilm formation successfully, assuming in accordance with the literature that when the negative regulators (RscCD and EnvZ/OmpR) are off, the positive regulator (FlhDC) is on. The network was modeled under three different conditions through time with satisfactory outcomes. Each cluster was constructed using the K-means/medians Clustering Support algorithm on the basis of published Affymetrix microarray gene expression data from biofilm-forming bacteria and the planktonic state over four time points for Escherichia coli K-12.Conclusions: The different phenotypes obtained demonstrate that the network model of biofilm formation can simulate the formation or repression of biofilm efficiently in E. coli K-12.


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Zuletzt aktualisiert 2019-23-08 um 11:15