ANTILEISHMANIAL ACTIVITY OF A TETRALONE ISOLATED FROM AMPELOCERA-EDENTULA, A BOLIVIAN PLANT USED AS A TREATMENT FOR CUTANEOUS LEISHMANIASIS

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Author list: FOURNET A, BARRIOS AA, MUNOZ V, HOCQUEMILLER R, ROBLOT F, CAVE A
Publisher: Georg Thieme Verlag
Publication year: 1994
Volume number: 60
Issue number: 1
Start page: 8
End page: 12
Number of pages: 5
ISSN: 0032-0943
Languages: English-Great Britain (EN-GB)


Abstract

The stem bark of Ampelocera edentula Kuhlm. (Ulmaceae) is used by the Chimanes Indians from Bolivia for the treatment of cutaneous leishmaniasis caused by the protozoan Leishmania braziliensis. A chloroform extract of the stem barks was found to be active against extracellular forms of Leishmania ssp. and Trypanosoma cruzi at 50 mu g/ml. Bioassay-guided fractionation of this extract allowed us to isolate one active compound. Its structure was elucidated by spectral and chemical studies as 4-hydroxyl-1-tetralone. BALB/e mice infected with L. amazonensis (PH8) or L. venezuelensis were treated one day after the parasitic infection with 4-hydroxy-1-tetralone (25 mg/ kg/day) or with reference drug, Glucantime(R) (56 mg Sb-v/kg/day) for 14 days. Lesion development was the criteria used to evaluate the disease severity. 4-Hydroxy-1-tetralone was slightly less effective than the reference drug against L. amazonensis or L. venezuelensis. Single treatment near the site of infection, 14 days after infection with L. amazonensis, with 4-hydroxy-1-tetralone (50 mg/kg) was more effective than Glucantime (112 mg/kg). This study is, to our knowledge, the first to show the activity of a tetralone for the experimental treatment of New World cutaneous leishmaniasis.


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Last updated on 2019-23-08 at 11:15