Identifying and characterizing the biological targets of metallotherapeutics

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Subtitle: Two approaches using Au(I)-protein interactions as model systems
Author list: Karver MR, Barrios AM
Publisher: Elsevier Masson
Publication year: 2008
Volume number: 382
Issue number: 1
Start page: 63
End page: 65
Number of pages: 3
ISSN: 0003-2697
Languages: English-Great Britain (EN-GB)


Abstract

A significant challenge in the field of medicinal inorganic chemistry is the identification of biological targets of metal-based drugs and the characterization of the metal-biomolecule adducts. A classic example is Au(I), which has long been used to treat rheumatoid arthritis despite a poor understanding of its biological targets due to the lability, reactivity, and "spectroscopic silence" that are characteristic of Au( I). Here, we report two qualitative methods for characterizing Au(I)-protein adducts: a thiol-reactive probe that facilitates the identification of biological cysteine-Au(I) adducts and a photoreactive Au(I) complex that produces a covalent bond between the Au(I) complex and the biomolecule. (C) 2008 Elsevier Inc. All rights reserved.


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Last updated on 2019-23-08 at 11:15