Identifying and characterizing the biological targets of metallotherapeutics

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Sous-titre: Two approaches using Au(I)-protein interactions as model systems
Liste des auteurs: Karver MR, Barrios AM
Editeur: Elsevier Masson
Année de publication: 2008
Numéro du volume: 382
Numéro de publication: 1
Page d'accueil: 63
Dernière page: 65
Nombre de pages: 3
ISSN: 0003-2697
Languages: Anglais-Royaume-Uni (EN-GB)


Résumé

A significant challenge in the field of medicinal inorganic chemistry is the identification of biological targets of metal-based drugs and the characterization of the metal-biomolecule adducts. A classic example is Au(I), which has long been used to treat rheumatoid arthritis despite a poor understanding of its biological targets due to the lability, reactivity, and "spectroscopic silence" that are characteristic of Au( I). Here, we report two qualitative methods for characterizing Au(I)-protein adducts: a thiol-reactive probe that facilitates the identification of biological cysteine-Au(I) adducts and a photoreactive Au(I) complex that produces a covalent bond between the Au(I) complex and the biomolecule. (C) 2008 Elsevier Inc. All rights reserved.


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Dernière mise à jour le 2019-23-08 à 11:15