Marine natural products as inhibitors of cystathionine beta-synthase activity

Journal article


Research Areas

No matching items found.

Publication Details

Author list: Thorson MK, Van Wagoner RM, Harper MK, Ireland CM, Majtan T, Kraus JP, Barrios AM
Publisher: Elsevier
Publication year: 2015
Volume number: 25
Issue number: 5
Start page: 1064
End page: 1066
Number of pages: 3
ISSN: 0960-894X
Languages: English-Great Britain (EN-GB)


A library consisting of characterized marine natural products as well as synthetic derivatives was screened for compounds capable of inhibiting the production of hydrogen sulfide (H2S) by cystathionine beta- synthase (CBS). Eight hits were validated and shown to inhibit CBS activity with IC50 values ranging from 83 to 187 mu M. The majority of hits came from a series of synthetic polyandrocarpamine derivatives. In addition, a modified fluorogenic probe for H2S detection with improved solubility in aqueous solutions is reported. (C) 2015 Elsevier Ltd. All rights reserved.


No matching items found.


No matching items found.

Last updated on 2019-23-08 at 11:15