Nasopharyngeal Colonization (NC) by Haemophilus influenzae

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Subtitle: 8 years after the introduction of the Haemophilus influenzae type b vaccination in the Argentine National Schedule
Author list: Romanin V, Chiavetta L, Salvay MC, Chiolo MJ, Regueira M, Barrios A, Califano G, Garcia S, Gentile A
Publisher: Sociedad Argentina de Pediatría
Publication year: 2007
Volume number: 105
Issue number: 6
Start page: 498
End page: 505
Number of pages: 8
ISSN: 0325-0075
Languages: English-Great Britain (EN-GB)


Introduction. As a part of the PAHO supported protocol "Evaluation of the impact of Haemophilus influenzae b vaccination programs in four Latinamerican countrys", a study took place in Argentine 8 years after introduction of Hib vaccine.Objective. To evaluate the impact of Hib vaccination measuring Nasopharyngeal Colonization (NC) rate and to identify factors associated to Haemophilus influeuzae (HI) carrier status.Methods. Cross-sectional study-from June 27(th) 2005 to April 12(th) 2006- in two pediatric hospitals, HNRG and PE. Nasopharyngeal swab specimens were processed in the INEI-ANLIS "Dr. C. Malbrzin"; samples were cultured in chocolate agar medium containing bacitracin. Hi was identified with technics of Gram, oxidase, catalase, growth factors (V-X-XV) and test of porphyrin. Capsular serotypification was made by agglutination in lamina with specific antisera and the confirmation by polymerase chain reaction.Population. 900 children of 1 year of age, vaccinated with 3 doses and 700 children of 5 years, with 4 vaccine doses.Results. Hi was detected in 40% (641 / 1.600) of samples, among Hi, 4,8% (31 / 641) were encapsulated (3 serotypes a, 1 b, 3 c, 5 d, 7 e, and 12 f). Only one child of I year was NC carrier of Hi type b (0.06%).Conclusions. We found a very low NC Hib (0.06%) rate, for this reason associations could not be analyzed. The age, household and day care center contacts were associated with NC by Haemophilus influenzae.


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Last updated on 2019-23-08 at 11:15