Parasite molecules and host responses in cystic echinococcosis

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Publication Details

Author list: Diaz A, Casaravilla C, Barrios AA, Ferreira AM
Publisher: Wiley: 12 months
Publication year: 2016
Journal: Parasite Immunology (0141-9838)
Volume number: 38
Issue number: 3
Start page: 193
End page: 205
Number of pages: 13
ISSN: 0141-9838
Languages: English-Great Britain (EN-GB)


Abstract

Cystic echinococcosis is the infection by the larvae of cestode parasites belonging to the Echinococcus granulosus sensu lato species complex. Local host responses are strikingly subdued in relation to the size and persistence of these larvae, which develop within mammalian organs as hydatid cysts' measuring up to tens of cm in diameter. In a context in which helminth-derived immune-suppressive, as well as Th2-inducing, molecules garner much interest, knowledge on the interactions between E.granulosus molecules and the immune system lags behind. Here, we discuss what is known and what are the open questions on E.granulosus molecules and structures interacting with the innate and adaptive immune systems, potentially or in demonstrated form. We attempt a global biological approach on molecules that have been given consideration primarily as protective (Eg95) or diagnostic antigens (antigen B, antigen 5). We integrate glycobiological information, which traverses the discussions on antigen 5, the mucin-based protective laminated layer and immunologically active preparations from protoscoleces. We also highlight some less well-known molecules that appear as promising candidates to possess immune-regulatory activities. Finally, we point out gaps in the molecular-level knowledge of this infectious agent that hinder our understanding of its immunology.


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Last updated on 2019-23-08 at 11:15