PDF-1 neuropeptide signaling modulates a neural circuit for mate-searching behavior in C. elegans

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Author list: Barrios A, Ghosh R, Fang C, Emmons SW, Barr MM
Publisher: Nature Research (part of Springer Nature)
Publication year: 2012
Volume number: 15
Issue number: 12
Start page: 1675
End page: +
ISSN: 1097-6256
Languages: English-Great Britain (EN-GB)


Abstract

Appetitive behaviors require complex decision making that involves the integration of environmental stimuli and physiological needs. C. elegans mate searching is a male-specific exploratory behavior regulated by two competing needs: food and reproductive appetite. We found that the pigment dispersing factor receptor (PDFR-1) modulates the circuit that encodes the male reproductive drive that promotes male exploration following mate deprivation. PDFR-1 and its ligand, PDF-1, stimulated mate searching in the male, but not in the hermaphrodite. pdf-1 was required in the gender-shared interneuron AIM, and the receptor acted in internal and external environment-sensing neurons of the shared nervous system (URY, PQR and PHA) to produce mate-searching behavior. Thus, the pdf-1 and pdfr-1 pathway functions in non-sex-specific neurons to produce a male-specific, goal-oriented exploratory behavior. Our results indicate that secretin neuropeptidergic signaling is involved in regulating motivational internal states.


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Last updated on 2019-23-08 at 11:17