Role of baseline human immunodeficiency virus genotype as a predictor of viral response to tenofovir in heavily pretreated patients

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Author list: Barrios A, de Mendoza C, Martin-Carbonero L, Ribera E, Domingo P, Galindo MJ, Galvez J, Estrada V, Dalmau D, Asensi V, Soriano V
Publisher: American Society for Microbiology
Publication year: 2003
Volume number: 41
Issue number: 9
Start page: 4421
End page: 4423
Number of pages: 3
ISSN: 0095-1137
Languages: English-Great Britain (EN-GB)


Human immunodeficiency virus (HIV)-infected patients (n = 153) failing antiretroviral therapy after exposure to compounds from all three drug families were monitored for 6 months after beginning a rescue intervention program including tenofovir (TDF). At 3 months, levels of HIV RNA in plasma dropped by a mean of 0.9 log(10) and the mean CD4 count increased by 52 cells/mul. At 6 months, HIV RNA levels had dropped by a mean of 1.06 log(10) and the mean CD4 count had increased by 49 cells/mul. Only five (3.7%) patients discontinued TDF use due to adverse events. In the multivariate analysis, the presence of M41L and/or L210W at baseline was the only viral determinant of a lower response to TDF.


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Last updated on 2019-23-08 at 11:15