Spectroscopic evidence for the formation of goldfingers

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Liste des auteurs: Franzman MA, Barrios AM
Editeur: American Chemical Society
Année de publication: 2008
Numéro du volume: 47
Numéro de publication: 10
Page d'accueil: 3928
Dernière page: 3930
Nombre de pages: 3
ISSN: 0020-1669
Languages: Anglais-Royaume-Uni (EN-GB)


Résumé

Gold(I) has long been used in the treatment of rheumatoid arthritis, but the therapeutically relevant biological targets of gold(I) are not well understood. Here, we report the results of a spectroscopic investigation into the formation of goldfingers. By exploiting a thiolate to gold charge-transfer band in the UV, we observed that gold(I) interacts with zinc finger peptides with a stoichiometry of one gold ion for each two cysteine residues, forming 1:1, 11.51, and 2:1 adducts with zinc finger peptides containing CCHH, CCHC, and CCCC donor sets, respectively. In addition, circular dichroism experiments provided evidence that goldfingers are more ordered than the corresponding metal-free peptides but do not exhibit the canonical zinc finger structure.


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