Medial temporal lobe neuromagnetic hypoactivation and risk for developing cognitive decline in elderly population

Journal article


Research Areas

Publication Details

Subtitle: A 2-year follow-up study
Author list: Maestú, F., Campo, P., Gil-Gregorio, P., Fernández, S., Fernández, A., Ortiz, T.
Publisher: Elsevier: 12 months
Publication year: 2006
Volume number: 27
Issue number: 1
Start page: 32
End page: 37
Number of pages: 6
ISSN: 0197-4580
Languages: English-Great Britain (EN-GB)


Cognition declines as a function of age. However, some elders could develop more severe status such as mild cognitive impairment (MCI). The aim of this study was the early detection of neurophysiological patterns of brain activity that may predict the possibility of certain subjects to develop MCI. Brain magnetic activity was recorded from 15 healthy subjects during a memory task by means of magnetoencephalography. None of the participants could be considered as MCI at the time of the first clinical evaluation. After 2-year follow-up, five subjects developed MCI and 10 maintained their cognitive status across time. The subjects who developed cognitive decline showed a lower number of activity sources in the left medial temporal lobe between 400 and 800 ms after stimulus onset, as compared to the non-cognitive decline group. These findings may help with the early identification of elderly subjects at high risk of cognitive decline, allowing the possibility of neuropsychological or pharmaceutical treatment that delay or prevent the progression of the cognitive impairment. © 2005 Elsevier Inc. All rights reserved.


No matching items found.


No matching items found.

Last updated on 2019-13-08 at 00:16