MEG Analysis of Neural Interactions in Attention-Deficit/Hyperactivity Disorder

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Publication Details

Author list: Fernández A
Publisher: Hindawi
Publication year: 2016
Volume number: 2016
Start page: 8450241
Number of pages: 10
ISSN: 1687-5265
Languages: English-Great Britain (EN-GB)


Abstract

The aim of the present study was to explore the interchannel
relationships of resting-state brain activity in patients with
attention-deficit/hyperactivity disorder (ADHD), one of the most common
mental disorders that develop in children. Magnetoencephalographic (MEG)
signals were recorded using a 148-channel whole-head magnetometer in 13
patients with ADHD (range: 8-12 years) and 14 control subjects (range:
8-13 years). Three complementary measures (coherence, phase-locking
value, and Euclidean distance) were calculated in the conventional MEG
frequency bands: delta, theta, alpha, beta, and gamma. Our results
showed that the interactions among MEG channels are higher for ADHD
patients than for control subjects in all frequency bands. Statistically
significant differences were observed for short-distance values within
right-anterior and central regions, especially at delta, beta, and
gamma-frequency bands (p<0.05; Mann-Whitney U test with false
discovery rate correction). These frequency bands also showed
statistically significant differences in long-distance interactions,
mainly among anterior and central regions, as well as among anterior,
central, and other areas. These differences might reflect alterations
during brain development in children with ADHD. Our results support the
role of frontal abnormalities in ADHD pathophysiology, which may reflect
a delay in cortical maturation in the frontal cortex.


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Last updated on 2019-13-08 at 00:16