Synchrony analysis of spontaneous MEG activity in Alzheimer's disease patients

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Author list: Gomez, Carlos; Martinez-Zarzuela, Mario; Poza, Jesus; Diaz-Pernas, Francisco J; Fernandez, Alberto; Hornero, Roberto
Publisher: IEEE
Publication year: 2012
Journal: Conference proceedings : Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual Conference (1557170X)
Volume number: 2012
Start page: 6188
End page: 6191
Number of pages: 4
ISSN: 1557170X
Languages: English-Great Britain (EN-GB)


The aim of this study was to analyze the magnetoencephalography (MEG)
background activity in Alzheimer's disease (AD) patients using
cross-approximate entropy (Cross-ApEn). Cross-ApEn is a nonlinear
measure of asynchrony between time series. Five minutes of recording
were acquired with a 148-channel whole-head magnetometer in 12 AD
patients and 12 age-matched control subjects. We found significantly
higher synchrony between MEG signals from AD patients compared with
control subjects. Additionally, we evaluated the ability of Cross-ApEn
to discriminate these two groups using receiver operating characteristic
(ROC) curves with a leave-one-out cross-validation procedure. We
obtained an accuracy of 70.83% (66.67% sensitivity, 75% specificity) and
a value of area under the ROC curve of 0.83. These results provide
evidence of disconnection problems in AD. Our findings show the
usefulness of Cross-ApEn to detect the brain dysfunction in AD.


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Last updated on 2019-13-08 at 00:16