Abnormal Social Reward Responses in Anorexia Nervosa

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Sous-titre: An fMRI Study
Liste des auteurs: Soriano-Mas C
Editeur: Public Library of Science
Année de publication: 2015
Journal: PLoS ONE (1932-6203)
Numéro du volume: 10
Numéro de publication: 7
Page d'accueil: e0133539
Nombre de pages: 20
ISSN: 1932-6203
eISSN: 1932-6203
Languages: Anglais-Royaume-Uni (EN-GB)


Patients with anorexia nervosa (AN) display impaired social
interactions, implicated in the development and prognosis of the
disorder. Importantly, social behavior is modulated by reward-based
processes, and dysfunctional at-brain-level reward responses have been
involved in AN neurobiological models. However, no prior evidence exists
of whether these neural alterations would be equally present in social
contexts. In this study, we conducted a cross-sectional social-judgment
functional magnetic resonance imaging (fMRI) study of 20
restrictive-subtype AN patients and 20 matched healthy controls. Brain
activity during acceptance and rejection was investigated and correlated
with severity measures (Eating Disorder Inventory -EDI-2) and with
personality traits of interest known to modulate social behavior (The
Sensitivity to Punishment and Sensitivity to Reward Questionnaire).
Patients showed hypoactivation of the dorsomedial prefrontal cortex
(DMPFC) during social acceptance and hyperactivation of visual areas
during social rejection. Ventral striatum activation during rejection
was positively correlated in patients with clinical severity scores.
During acceptance, activation of the frontal opercula-anterior insula
and dorsomedial/dorsolateral prefrontal cortices was differentially
associated with reward sensitivity between groups. These results suggest
an abnormal motivational drive for social stimuli, and involve
overlapping social cognition and reward systems leading to a disruption
of adaptive responses in the processing of social reward. The specific
association of reward-related regions with clinical and psychometric
measures suggests the putative involvement of reward structures in the
maintenance of pathological behaviors in AN.


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