Beneficial effect of donepezil on sensorimotor function after stroke




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Details zur Publikation

Autorenliste: Soriano-Mas C
Verlag: Lippincott, Williams & Wilkins
Jahr der Veröffentlichung: 2003
Zeitschrift: American Journal of Physical Medicine and Rehabilitation (0894-9115)
Bandnummer: 82
Heftnummer: 9
Erste Seite: 725
Letzte Seite: 729
Seitenumfang: 5
ISSN: 0894-9115
Sprachen: Englisch-Vereinigtes Königreich (EN-GB)


Pharmacotherapy of poststroke sensorimotor deficits is currently used
alone or combined with physiotherapy to promote recovery of mobility
problems. This case study examined the effectiveness of donepezil
hydrochloride (HCl) administered to a stroke patient with chronic,
dense, left sensorimotor deficit. The patient received donepezil HCl (5
mg daily for 4 wk, followed by 10 mg daily for 12 wk) but no
physiotherapy. Baseline and posttreatment evaluations were performed
with the Fugl-Meyer scale and the Rivermead Mobility Index. One month
after starting donepezil HCl (10 mg/day), sensorimotor function improved
dramatically in the hemiplegic lower limb and shoulder. It was
concluded that donepezil HCl may be an effective treatment for improving
sensorimotor function in chronic stroke patients. Randomized controlled
trials are required to support these preliminary findings.


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Zuletzt aktualisiert 2019-13-08 um 00:45