Beneficial effect of donepezil on sensorimotor function after stroke

Journal article


Research Areas

No matching items found.

Publication Details

Author list: Soriano-Mas C
Publisher: Lippincott, Williams & Wilkins
Publication year: 2003
Journal: American Journal of Physical Medicine and Rehabilitation (0894-9115)
Volume number: 82
Issue number: 9
Start page: 725
End page: 729
Number of pages: 5
ISSN: 0894-9115
Languages: English-Great Britain (EN-GB)


Pharmacotherapy of poststroke sensorimotor deficits is currently used
alone or combined with physiotherapy to promote recovery of mobility
problems. This case study examined the effectiveness of donepezil
hydrochloride (HCl) administered to a stroke patient with chronic,
dense, left sensorimotor deficit. The patient received donepezil HCl (5
mg daily for 4 wk, followed by 10 mg daily for 12 wk) but no
physiotherapy. Baseline and posttreatment evaluations were performed
with the Fugl-Meyer scale and the Rivermead Mobility Index. One month
after starting donepezil HCl (10 mg/day), sensorimotor function improved
dramatically in the hemiplegic lower limb and shoulder. It was
concluded that donepezil HCl may be an effective treatment for improving
sensorimotor function in chronic stroke patients. Randomized controlled
trials are required to support these preliminary findings.


No matching items found.


No matching items found.

Last updated on 2019-13-08 at 00:45