Brain corticostriatal systems and the major clinical symptom dimensions of obsessive-compulsive disorder

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Publication Details

Author list: Soriano-Mas C
Publisher: Elsevier: 12 months
Publication year: 2013
Journal: Biological Psychiatry (0006-3223)
Volume number: 73
Issue number: 4
Start page: 321
End page: 328
Number of pages: 8
ISSN: 0006-3223
Languages: English-Great Britain (EN-GB)


Abstract

BACKGROUND:

Functional
neuroimaging studies have provided consistent support for the idea that
obsessive-compulsive disorder (OCD) is associated with disturbances of
brain corticostriatal systems. However, in general, these studies have
not sought to account for the disorder's prominent clinical
heterogeneity.

METHODS:

To
address these concerns, we investigated the influence of major OCD
symptom dimensions on brain corticostriatal functional systems in a
large sample of OCD patients (n = 74) and control participants (n = 74)
examined with resting-state functional magnetic resonance imaging. We
employed a valid method for mapping ventral and dorsal striatal
functional connectivity, which supported both standard group comparisons
and linear regression analyses with patients' scores on the Dimensional
Yale-Brown Obsessive-Compulsive Scale.

RESULTS:

Consistent
with past findings, patients demonstrated a common connectivity
alteration involving the ventral striatum and orbitofrontal cortex that
predicted overall illness severity levels. This common alteration was
independent of the effect of particular symptom dimensions. Instead, we
observed distinct anatomical relationships between the severity of
symptom dimensions and striatal functional connectivity. Aggression
symptoms modulated connectivity between the ventral striatum, amygdala,
and ventromedial frontal cortex, while sexual/religious symptoms had a
specific influence on ventral striatal-insular connectivity. Hoarding
modulated the strength of ventral and dorsal striatal connectivity with
distributed frontal regions.

CONCLUSIONS:

Taken
together, these results suggest that pathophysiological changes among
orbitofrontal-striatal regions may be common to all forms of OCD. They
suggest that a further examination of certain dimensional relationships
will also be relevant for advancing current neurobiological models of
the disorder.


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Last updated on 2019-13-08 at 00:45