Brain structural alterations in obsessive-compulsive disorder patients with autogenous and reactive obsessions

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Publication Details

Author list: Soriano-Mas C
Publisher: Public Library of Science
Publication year: 2013
Journal: PLoS ONE (1932-6203)
Volume number: 8
Issue number: 9
Start page: e75273
Number of pages: 8
ISSN: 1932-6203
eISSN: 1932-6203
Languages: English-Great Britain (EN-GB)


Obsessive-compulsive disorder (OCD) is a clinically heterogeneous
condition. Although structural brain alterations have been consistently
reported in OCD, their interaction with particular clinical subtypes
deserves further examination. Among other approaches, a two-group
classification in patients with autogenous and reactive obsessions has
been proposed. The purpose of the present study was to assess, by means
of a voxel-based morphometry analysis, the putative brain structural
correlates of this classification scheme in OCD patients. Ninety-five
OCD patients and 95 healthy controls were recruited. Patients were
divided into autogenous (n = 30) and reactive (n = 65) sub-groups. A
structural magnetic resonance image was acquired for each participant
and pre-processed with SPM8 software to obtain a volume-modulated gray
matter map. Whole-brain and voxel-wise comparisons between the study
groups were then performed. In comparison to the autogenous group,
reactive patients showed larger gray matter volumes in the right
Rolandic operculum. When compared to healthy controls, reactive patients
showed larger volumes in the putamen (bilaterally), while autogenous
patients showed a smaller left anterior temporal lobe. Also in
comparison to healthy controls, the right middle temporal gyrus was
smaller in both patient subgroups. Our results suggest that autogenous
and reactive obsessions depend on partially dissimilar neural
substrates. Our findings provide some neurobiological support for this
classification scheme and contribute to unraveling the neurobiological
basis of clinical heterogeneity in OCD.


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Last updated on 2019-13-08 at 00:45