Brain structural correlates of depressive comorbidity in obsessive-compulsive disorder

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Details zur Publikation

Autorenliste: Soriano-Mas C
Verlag: Elsevier
Jahr der Veröffentlichung: 2007
Zeitschrift: NeuroImage (1053-8119)
Bandnummer: 38
Heftnummer: 3
Erste Seite: 413
Letzte Seite: 421
Seitenumfang: 9
ISSN: 1053-8119
Sprachen: Englisch-Vereinigtes Königreich (EN-GB)


Beschreibung

The high comorbidity of obsessive-compulsive disorder (OCD) with major
depressive disorder (MDD) suggests common neurobiological substrates. We
assessed the contribution of lifetime MDD to brain structural
alterations in OCD using magnetic resonance imaging. OCD patients with
(n=33) or without (n=39) lifetime MDD, and 72 control subjects were
assessed. Comparative region of interest (ROI) analyses assessed the
contribution of lifetime MDD to gray matter volume alterations in OCD
patients. Interregional correlations of gray matter volume were also
examined and voxelwise analyses were performed to identify alterations
in other brain regions. OCD patients with lifetime MDD showed a larger
reduction of medial orbitofrontal cortex (mOFC) gray matter volume. Both
OCD groups showed distinct correlations of mOFC gray matter volume with
other relevant brain regions. For patients with MDD, this involved the
medial frontal gyrus, and right insula and amygdala regions, whereas for
those OCD patients without MDD, the rostral anterior cingulate cortex
was involved. Our findings support existing evidence suggesting a
non-specific involvement of mOFC alterations in a range of
neuropsychiatric disorders. Nevertheless, volume reduction in this
region, together with an abnormal pattern of interregional correlations
with other emotion-relevant brain areas, may contribute to explain the
diathesis for MDD comorbidity in OCD.


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