Brain structural correlates of reward sensitivity and impulsivity in adolescents with normal and excess weight

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Publication Details

Author list: Soriano-Mas C
Publisher: Public Library of Science
Publication year: 2012
Journal: PLoS ONE (1932-6203)
Volume number: 7
Issue number: 11
Start page: e49185
Number of pages: 8
ISSN: 1932-6203
eISSN: 1932-6203
Languages: English-Great Britain (EN-GB)


Abstract

INTRODUCTION: Neuroscience evidence suggests that adolescent obesity is
linked to brain dysfunctions associated with enhanced reward and
somatosensory processing and reduced impulse control during food
processing. Comparatively less is known about the role of more stable
brain structural measures and their link to personality traits and
neuropsychological factors on the presentation of adolescent obesity.
Here we aimed to investigate regional brain anatomy in adolescents with
excess weight vs. lean controls. We also aimed to contrast the
associations between brain structure and personality and cognitive
measures in both groups. METHODS: Fifty-two adolescents (16 with normal
weight and 36 with excess weight) were scanned using magnetic resonance
imaging and completed the Sensitivity to Punishment and Sensitivity to
Reward Questionnaire (SPSRQ), the UPPS-P scale, and the Stroop task.
Voxel-based morphometry (VBM) was used to assess possible between-group
differences in regional gray matter (GM) and to measure the putative
differences in the way reward and punishment sensitivity, impulsivity
and inhibitory control relate to regional GM volumes, which were
analyzed using both region of interest (ROI) and whole brain analyses.
The ROIs included areas involved in reward/somatosensory processing
(striatum, somatosensory cortices) and motivation/impulse control
(hippocampus, prefrontal cortex). RESULTS: Excess weight adolescents
showed increased GM volume in the right hippocampus. Voxel-wise volumes
of the second somatosensory cortex (SII) were correlated with reward
sensitivity and positive urgency in lean controls, but this association
was missed in excess weight adolescents. Moreover, Stroop performance
correlated with dorsolateral prefrontal cortex volumes in controls but
not in excess weight adolescents. CONCLUSION: Adolescents with excess
weight have structural abnormalities in brain regions associated with
somatosensory processing and motivation.


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Last updated on 2019-13-08 at 00:45