Brain structural correlates of sensory phenomena in patients with obsessive-compulsive disorder

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Publication Details

Author list: Soriano-Mas C
Publisher: Canadian Medical Association
Publication year: 2015
Journal: Journal of Psychiatry and Neuroscience (1180-4882)
Volume number: 40
Issue number: 4
Start page: 232
End page: 240
Number of pages: 9
ISSN: 1180-4882
Languages: English-Great Britain (EN-GB)


Abstract

Sensory phenomena (SP) are uncomfortable feelings, including bodily
sensations, sense of inner tension, "just-right" perceptions, feelings
of incompleteness, or "urge-only" phenomena, which have been described
to precede, trigger or accompany repetitive behaviours in individuals
with obsessive-compulsive disorder (OCD). Sensory phenomena are also
observed in individuals with tic disorders, and previous research
suggests that sensorimotor cortex abnormalities underpin the presence of
SP in such patients. However, to our knowledge, no studies have
assessed the neural correlates of SP in patients with OCD.We assessed
the presence of SP using the University of São Paulo Sensory Phenomena
Scale in patients with OCD and healthy controls from specialized units
in São Paulo, Brazil, and Barcelona, Spain. All participants underwent a
structural magnetic resonance examination, and brain images were
examined using DARTEL voxel-based morphometry. We evaluated grey matter
volume differences between patients with and without SP and healthy
controls within the sensorimotor and premotor cortices.We included 106
patients with OCD and 87 controls in our study. Patients with SP (67% of
the sample) showed grey matter volume increases in the left
sensorimotor cortex in comparison to patients without SP and bilateral
sensorimotor cortex grey matter volume increases in comparison to
controls. No differences were observed between patients without SP and
controls.Most patients were medicated. Participant recruitment and image
acquisition were performed in 2 different centres.We have identified a
structural correlate of SP in patients with OCD involving grey matter
volume increases within the sensorimotor cortex; this finding is in
agreement with those of tic disorder studies showing that abnormal
activity and volume increases within this region are associated with the
urges preceding tic onset.


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Last updated on 2019-13-08 at 00:45