Brain substrates of social decision-making in dual diagnosis: cocaine dependence and personality disorders

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Liste des auteurs: Soriano-Mas C
Editeur: Wiley: 12 months
Année de publication: 2015
Journal: Addiction Biology (1355-6215)
Numéro du volume: 22
Numéro de publication: 2
Page d'accueil: 457
Dernière page: 467
Nombre de pages: 11
ISSN: 1355-6215
eISSN: 1369-1600
Languages: Anglais-Royaume-Uni (EN-GB)


Cocaine dependence frequently co-occurs with personality disorders,
leading to increased interpersonal problems and greater burden of
disease. Personality disorders are characterised by patterns of thinking
and feeling that divert from social expectations. However, the
comorbidity between cocaine dependence and personality disorders has not
been substantiated by measures of brain activation during social
decision-making. We applied functional magnetic resonance imaging to
compare brain activations evoked by a social decision-making task-the
Ultimatum Game-in 24 cocaine dependents with personality disorders
(CDPD), 19 cocaine dependents without comorbidities and 19 healthy
controls. In the Ultimatum Game participants had to accept or reject
bids made by another player to split monetary stakes. Offers varied in
fairness (in fair offers the proposer shares ~50 percent of the money;
in unfair offers the proposer shares <30 percent of the money), and
participants were told that if they accept both players get the money,
and if they reject both players lose it. We contrasted brain activations
during unfair versus fair offers and accept versus reject choices.
During evaluation of unfair offers CDPD displayed lower activation in
the insula and the anterior cingulate cortex and higher activation in
the lateral orbitofrontal cortex and superior frontal and temporal gyri.
Frontal activations negatively correlated with emotion recognition.
During rejection of offers CDPD displayed lower activation in the
anterior cingulate cortex, striatum and midbrain. Dual diagnosis is
linked to hypo-activation of the insula and anterior cingulate cortex
and hyper-activation of frontal-temporal regions during social
decision-making, which associates with poorer emotion recognition.


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