Dynamic functional connectivity reveals altered variability in functional connectivity among patients with major depressive disorder

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Publication Details

Author list: Soriano-Mas C
Publisher: Wiley: 12 months
Publication year: 2016
Journal: Human Brain Mapping (1065-9471)
Volume number: 37
Issue number: 8
Start page: 2918
End page: 2930
Number of pages: 13
ISSN: 1065-9471
eISSN: 1097-0193
Languages: English-Great Britain (EN-GB)


Resting-state fMRI (RS-fMRI) has become a useful tool to investigate the
connectivity structure of mental health disorders. In the case of major
depressive disorder (MDD), recent studies regarding the RS-fMRI have
found abnormal connectivity in several regions of the brain,
particularly in the default mode network (DMN). Thus, the relevance of
the DMN to self-referential thoughts and ruminations has made the use of
the resting-state approach particularly important for MDD. The majority
of such research has relied on the grand averaged functional
connectivity measures based on the temporal correlations between the
BOLD time series of various brain regions. We, in our study,
investigated the variations in the functional connectivity over time at
global and local level using RS-fMRI BOLD time series of 27 MDD patients
and 27 healthy control subjects. We found that global synchronization
and temporal stability were significantly increased in the MDD patients.
Furthermore, the participants with MDD showed significantly increased
overall average (static) functional connectivity (sFC) but decreased
variability of functional connectivity (vFC) within specific networks.
Static FC increased to predominance among the regions pertaining to the
default mode network (DMN), while the decreased variability of FC was
observed in the connections between the DMN and the frontoparietal


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Last updated on 2019-13-08 at 00:16