Neural correlates of minor hallucinations in non-demented patients with Parkinson's disease

Zeitschriftenaufsatz


Autoren/Herausgeber


Forschungsfelder

Es wurden keine entsprechenden Inhalte gefunden.


Details zur Publikation

Autorenliste: Soriano-Mas C
Verlag: Elsevier
Jahr der Veröffentlichung: 2014
Zeitschrift: Parkinsonism and Related Disorders (1353-8020)
Bandnummer: 20
Heftnummer: 3
Erste Seite: 290
Letzte Seite: 296
Seitenumfang: 7
ISSN: 1353-8020
Sprachen: Englisch-Vereinigtes Königreich (EN-GB)


Beschreibung

BACKGROUND: Hallucinations are a frequent and severe complication in
Parkinson's disease (PD). Minor hallucinations are generally not
disturbing, but likely progress to well-structured hallucinations with
loss of insight and a great impact on quality of life. Knowledge on the
neural bases of minor hallucinations may help to describe those systems
associated with the early development of psychotic phenomena in PD. In
this study, we aimed to identify the pattern of structural brain
alterations associated with minor hallucinations in PD by using
voxel-based morphometry (VBM). METHODS: We prospectively collected a
sample of 46 non-demented PD patients, with (N = 17) and without (n =
29) minor hallucinations (passage and/or presence hallucinations), and
15 healthy controls. Groups were matched for age, education and global
cognitive function. Presence and type of minor psychotic phenomena was
assessed by the new MDS-UPDRS. Three dimensional T1-weighted MRI images
were acquired with a 1.5 T magnet, and analyzed using optimized VBM.
RESULTS: Compared to controls, PD with minor hallucinations (PD-mH)
showed reduced gray matter volume bilaterally in different areas of the
dorsal visual stream, and in functionally related midbrain and
cerebellar structures. Additionally, bilateral gray matter volume
increases were observed in the PD-mH group in limbic and paralimbic
regions. CONCLUSIONS: Our data support a major role of the dorsal visual
stream in the genesis of minor hallucinations in PD, reinforcing the
importance of posterior cortical regions for the development of
cognitive and psychiatric complications in PD.


Schlagwörter

Es wurden keine entsprechenden Inhalte gefunden.


Dokumente

Es wurden keine entsprechenden Inhalte gefunden.

Zuletzt aktualisiert 2019-13-08 um 00:45