Re-appraisal of negative emotions in cocaine dependence: dysfunctional corticolimbic activation and connectivity

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Publication Details

Author list: Soriano-Mas C
Publisher: Wiley: 12 months
Publication year: 2014
Journal: Addiction Biology (1355-6215)
Volume number: 19
Issue number: 3
Start page: 415
End page: 426
Number of pages: 12
ISSN: 1355-6215
eISSN: 1369-1600
Languages: English-Great Britain (EN-GB)


Abstract

Cocaine dependence is associated with pronounced elevations of negative
affect and deficient regulation of negative emotions. We aimed to
investigate the neural substrates of negative emotion regulation in
cocaine-dependent individuals (CDI), as compared to non-drug-using
controls, using functional magnetic resonance imaging (fMRI) during a
re-appraisal task. Seventeen CDI abstinent for at least 15 days and
without other psychiatric co-morbidities and 18 intelligence
quotient-matched non-drug-using controls participated in the study.
Participants performed the re-appraisal task during fMRI scanning: they
were exposed to 24 blocks of negative affective or neutral pictures that
they should Observe (neutral pictures), Maintain (sustain the emotion
elicited by negative pictures) or Suppress (regulate the emotion
elicited by negative pictures through previously trained re-appraisal
techniques). Task-related activations during two conditions of interest
(Maintain>Observe and Suppress>Maintain) were analyzed using the
general linear model in SPM8 software. We also performed
psychophysiological interaction (PPI) seed-based analyses based on one
region from each condition: the dorsolateral prefrontal cortex
(dlPFC-Maintain>Observe) and the inferior frontal gyrus
(IFG-Suppress>Maintain). Results showed that cocaine users had
increased right dlPFC and bilateral temporoparietal junction activations
during Maintain>Observe, whereas they showed decreased right IFG,
posterior cingulate cortex, insula and fusiform gyrus activations during
Suppress>Maintain. PPI analyses showed that cocaine users had
increased functional coupling between the dlPFC and emotion-related
regions during Maintain>Observe, whereas they showed decreased
functional coupling between the right IFG and the amygdala during
Suppress>Maintain. These findings indicate that CDI have
dysfunctional corticolimbic activation and connectivity during negative
emotion experience and re-appraisal.


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Last updated on 2019-13-08 at 00:45