The interaction between Comt and Bdnf variants influences obsessive-compulsive-related dysfunctional beliefs

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Publication Details

Author list: Soriano-Mas C
Publisher: Elsevier
Publication year: 2013
Journal: Journal of Anxiety Disorders (0887-6185)
Volume number: 27
Issue number: 3
Start page: 321
End page: 327
Number of pages: 7
ISSN: 0887-6185
Languages: English-Great Britain (EN-GB)


Abstract

Cognitive models emphasize the importance of dysfunctional beliefs as
overimportance/need to control thoughts, perfectionism, intolerance of
uncertainty, responsibility, and overestimation of threat in
obsessive-compulsive disorder (OCD). Twin studies suggest that these
beliefs are significantly heritable, but candidate genes associated with
them have not been analyzed. We genotyped the Val158Met in the COMT
gene and Val66Met variant in the BDNF gene in 141 OCD patients and
analyzed their single and interactive effects on the obsessive beliefs
questionnaire (OBQ-44). Variability in dysfunctional beliefs was not
affected by the COMT or BDNF genotype in isolation, but we detected a
significant COMT×BDNF interaction effect on
responsibility/overestimation of threat and overimportance/need to
control thoughts scores. Subjects with the BDNF Met-present and the COMT
Met-present genotype showed higher scores on
responsibility/overestimation of threat. An interaction between
dopaminergic and neurotrophic functional gene variants may influence
dysfunctional beliefs hypothesized to contribute to the development of
OCD.


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Last updated on 2019-13-08 at 00:45