Variations in the shape of the frontobasal brain region in obsessive-compulsive disorde

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Liste des auteurs: Soriano-Mas C
Editeur: Wiley: 12 months
Année de publication: 2011
Journal: Human Brain Mapping (1065-9471)
Numéro du volume: 32
Numéro de publication: 7
Page d'accueil: 1100
Dernière page: 1108
Nombre de pages: 9
ISSN: 1065-9471
eISSN: 1097-0193
Languages: Anglais-Royaume-Uni (EN-GB)


Obsessive-compulsive disorder (OCD) emerges during childhood through
young adulthood coinciding with the late phases of postnatal brain
development when fine remodeling of brain anatomy takes place. Previous
research has suggested the existence of subtle anatomical alterations in
OCD involving focal volume variations in different brain regions
including the frontal lobes and basal ganglia. We investigated whether
anatomical changes might also involve variations in the shape of the
frontobasal region. A total of 101 OCD patients and 101 control subjects
were examined using magnetic resonance imaging. A cross-sectional image
highly representative of frontal-basal ganglia anatomy was selected in
each individual and 25 reliable anatomical landmarks were identified to
assess shape changes. A pixel-wise morphing approach was also used to
dynamically illustrate the findings. We found significant group
differences for overall landmark position and for most individual
landmarks delimiting the defined frontobasal region. OCD patients showed
a deformation pattern involving shortening of the anterior-posterior
dimension of the frontal lobes and basal ganglia, and enlargement of
cerebrospinal fluid spaces around the frontal opercula. In addition, we
observed significant correlation of brain tissue shape variation with
frontal sinus size. Identification of a global change in the shape of
the frontobasal region may further contribute to characterizing the
nature of brain alterations in OCD. The coincidence of brain shape
variations with morphological changes in the frontal sinus indicates a
potential association of OCD to late development disturbances, as the
frontal sinus macroscopically emerges during the transition between
childhood and adulthood.


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