Assessment of electroencephalographic functional connectivity in term and preterm neonates

Journal article


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Publication Details

Author list: Pereda E
Publisher: Elsevier: 12 months
Publication year: 2011
Volume number: 122
Issue number: 4
Start page: 696
End page: 702
Number of pages: 7
ISSN: 1388-2457
Languages: English-Great Britain (EN-GB)


Abstract

OBJECTIVE:

To
study how functional connectivity of neonate EEG during sleep is
assessed by different interdependence indices and to analyze its
dependence on conceptional (CA), gestational (GA) and/or chronological
age (CRA).

METHODS:

EEG
data from eight cortical regions were recorded during active (AS) and
quiet sleep (QS) in three groups of seven neonates each: preterm (PT;
GA: 33-34 weeks; CA: 39-40 weeks), junior-term (JT; GA: 38-39 weeks; CA:
39-40 weeks) and senior-term neonates (ST; GA: 38-39 weeks; CA: 44-45
weeks). EEG functional connectivity was assessed by means of the
coherence function (its magnitude (MSC) and its imaginary part (IMC))
and a measure of phase synchronization called phase lag index (PLI).

RESULTS:

Inter-hemispheric
connectivity: (a) during AS in the beta band, the MSC of the ST group
was greater than that of the PT group for the temporal region; (b)
during QS in the delta band, both PLI and IMC of the ST group were
different to those of the PT group for the frontopolar and central
regions, whereas ST-JT differences were only found for PLI.
Intra-hemispheric connectivity: (a) during AS in the beta band the MSC
of the ST group was greater than that of the PT group for the left
frontopolar-centrotemporal and right occipital-centrotemporal regions;
(b) during QS in the beta band, both IMC and PLI were different for the
JT group than for the PT and the ST groups for the right and left
occipital-centrotemporal regions.

CONCLUSIONS:

EEG
inter- and intra-hemispheric functional connectivity in neonates during
sleep changes with the CA and CRA in delta and beta bands.

SIGNIFICANCE:

The
neonate's brain development during the first weeks of life can be
traced from changes in the characteristics of EEG functional
connectivity.


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Last updated on 2019-13-08 at 00:45