Can symptoms help in differential diagnosis between substance-induced vs independent psychosis in adults with a lifetime diagnosis of cocaine use disorder?

The main goal of this study it is explore the psychopathological
differences between IPD and SIPD in a sample of 125 adults with a
lifetime diagnosis of cocaine disorder recruited from treatment setting
and through street contacts. A secondary analysis of six cross-sectional
studies was conducted between 2000 and 2010. SIPD and IPD were
diagnosed using the Psychiatric Research Interview for Substance and
Mental Disorders (PRISM). 38 subjects (30.4%) were diagnosed with
lifetime IPD and 87 (69.6%) with lifetime SIPD. A binomial logistic
regression analysis using SIPD as the reference group showed that only
previous prison admissions (OR 2.59; 95% CI 1.05, 6.36) and visual
hallucinations (OR 5.21; 95% CI 1.54, 17.65) remained significant
variables in the group with lifetime SIPD. In the group with lifetime
IPD, grandiose delusions (OR 0.19; 95% CI 0.06, 0.60) and disorganized
speech (OR 0.16; 95% CI 0.04, 0.61) remained significant. Model predicts
the diagnosis of lifetime SIPD with a sensitivity of 80.3% and a
specificity of 78.2%. This clinical profile of lifetime SIPD could help
distinguish between IPD and SIPD among adults with lifetime diagnosis of
cocaine disorder.