A clinical and magnetoencephalography study of MRI-negative startle epilepsy

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Publication Details

Author list: Maestu F
Publisher: Elsevier
Publication year: 2009
Volume number: 16
Issue number: 1
Start page: 166
End page: 171
Number of pages: 6
ISSN: 1525-5050
Languages: English-Great Britain (EN-GB)


Objective: The goal of this study was to investigate clinical findings,
ictal semiology, and results of video/electroencephalography
(video/EEG), and magnetoencephalography (MEG) in patients with startle
epilepsy and normal brain MRI.

Methods: Four patients (mean age 12.5 years) with startle epilepsy were investigated with MRI, video/EEG, and MEG.

Results: Epilepsy diagnosis was established in childhood, and all
had spontaneous and reflex seizures. Reflex seizures were triggered by
sudden, unexpected sounds and tactile stimuli. The neurological
examinations and MRIs were normal. MEG recordings showed focal
epileptiform activity. An ictal MEG was obtained in one patient. Source
modeling yielded dipole sources in right central frontal region.

Conclusion: The present study demonstrates that the origin of
epileptiform activity in startle epilepsy can be localized in brain
areas associated with supplementary motor seizures, even in patients
with normal brain MRI. MEG adds complementary information to the
localization of epileptiform activity and can be useful in planning
invasive studies in cases evaluated for epilepsy surgery.


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Last updated on 2019-13-08 at 00:45