Biomagnetic profiles of verbal memory success in patients with mesial temporal lobe epilepsy




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Details zur Publikation

Autorenliste: Maestu F
Verlag: Elsevier
Jahr der Veröffentlichung: 2009
Bandnummer: 16
Heftnummer: 3
Erste Seite: 527
Letzte Seite: 533
Seitenumfang: 7
ISSN: 1525-5050
Sprachen: Englisch-Vereinigtes Königreich (EN-GB)


The risk of cognitive decline after mesial temporal lobe (MTL) resection
in the dominant hemisphere for treatment of epilepsy has been assessed
with the intracarotid amytal procedure and functional neuroimaging. In
this study we used magnetoencephalography (MEG) to analyze memory
profiles in patients with left hippocampal sclerosis (HS). Biomagnetic
brain activity related to successful memory was compared in nine
patients with left HS and nine age-matched controls. Patients manifested
a higher number of activity sources over the right inferior parietal
lobe in the late portion of the time window, and higher activity in the
right than in the left MTL between 400 and 800 ms. This was reinforced
by a -0.46 MTL laterality index, which indicates right MTL dominance.
Controls showed a higher number of dipoles in the left anterior ventral
prefrontal region, between 400 and 600 ins, and in the left MTL across
the whole time window. Three patients who underwent a left temporal
lobectomy, were seizure free, and who did not exhibit memory impairment
after left temporal lobectomy, showed no activity in the left MTL
presurgically. These results Could support the ability of MEG to
describe the time-modulated brain activity related to memory success in
patients with epilepsy with left HS.


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Zuletzt aktualisiert 2019-13-08 um 00:45