Brain Activity Patterns in Stable and Progressive Mild Cognitive Impairment During Working Memory as Evidenced by Magnetoencephalography

Journal article


Research Areas

No matching items found.

Publication Details

Author list: Maestu F
Publisher: Lippincott, Williams & Wilkins
Publication year: 2011
Volume number: 28
Issue number: 2
Start page: 202
End page: 209
Number of pages: 8
ISSN: 0736-0258
Languages: English-Great Britain (EN-GB)


It has been reported that mild cognitive impairment (MCI) patients, when
compared with controls, show increased activity in different brain
regions within the ventral pathway during memory tasks. A key question
is whether this profile of increased activity could be useful to predict
which patients will develop dementia. Herein, we present profiles of
brain magnetic activity during a memory task recorded with
magnetoencephalography from MCI patients (N = 10), Alzheimer's disease
(AD) patients (N = 10), and healthy volunteers (N = 17). After 2 1/2
years of follow-up, five of the MCI patients developed AD. Patients who
progressed to AD (PMCI) showed higher activity than those who remained
stable (SMCI), AD patients and controls. This increased activity in PMCI
patients involves regions within the ventral and dorsal pathways. In
contrast, SMCI patients showed higher activation than controls only
along the ventral pathway. This increase in both the ventral and dorsal
pathways in PMCI patients may reflect a compensatory mechanism for the
loss in efficiency in memory networks, which would be absent in AD
patients as they showed lower activity levels than the rest of the


No matching items found.


No matching items found.

Last updated on 2019-13-08 at 00:45