Brain structural and functional recovery following initiation of combination antiretroviral therapy

Journal article


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Publication Details

Author list: Maestu F
Publisher: Springer Verlag (Germany) / Taylor & Francis: STM, Behavioural Science and Public Health Titles
Publication year: 2012
Volume number: 18
Issue number: 5
Start page: 423
End page: 427
Number of pages: 5
ISSN: 1355-0284
Languages: English-Great Britain (EN-GB)


NeuroAIDS persists in the era of combination antiretroviral therapies.
We describe here the recovery of brain structure and function following 6
months of therapy in a treatment-naive patient presenting with
HIV-associated dementia. The patient's neuropsychological test
performance improved and his total brain volume increased by more than 5
%. Neuronal functional connectivity measured by magnetoencephalography
changed from a pattern identical to that observed in other HIV-infected
individuals to one that was indistinguishable from that of uninfected
control subjects. These data suggest that at least some of the effects
of HIV on the brain can be fully reversed with treatment.


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Last updated on 2019-13-08 at 00:45