Cerebral perfusion during word repetition in epileptic patients

Journal article


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Publication Details

Author list: Maestu F
Publisher: Cesar Viguera
Publication year: 2001
Journal: Revista de Neurologia (0210-0010)
Volume number: 32
Issue number: 1
Start page: 6
End page: 10
Number of pages: 5
ISSN: 0210-0010
Languages: English-Great Britain (EN-GB)


Objective. To localize the cortical regions for language in patients who
are to have brain surgery. Patients and methods. We made a SPECT
(Single Photon Emission using Computerized Tomography) study of cerebral
perfusion in 14 patients with drug-resistant temporal epilepsy who were
candidates for brain surgery. The patients were selected consecutively
from those attending for surgical assessment. We selected the patients
in whom two Tc-99m-HMPAO studies could be clone in the same week: one
without sensory stimulation and one whilst listening and repeating a
series of ordinary words in fairly frequent use. The two studies were
assessed qualitatively (on a 16 colour image scale, with a background
subtraction of 20% and standardized to the point of maximum uptake).
Changes were considered to be significant when a greater intensity of
two colours was localized and semiquantitative (with regular areas of
interest, of 4x4 pixels, placed on the region in which the qualitative
change was observed and referenced to cerebellar activity). Results. We
found increased perfusion in the temporo-parietal regions in II of the
14 patients. In most (9/14 eases) this was bilateral and in two eases on
the left only. We observed a certain predominant pattern: a bilateral
increase in temporal perfusion, involving the more anterior regions of
the left hemisphere and also the middle and posterior regions of the
right hemisphere. The maximum percentage increase in perfusion on
semiquantitative assessment was 12%. Conclusion. Although the changes
seen may correspond to activation in the cortical regions related to
different cerebral functions, we consider that with the SPECT technique
one may detect changes in perfusion of the regions of the brain which
are involved in language processing.


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Last updated on 2019-10-08 at 00:15