Correlations of hippocampal atrophy and focal low-frequency magnetic activity in Alzheimer disease

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Publication Details

Subtitle: Volumetric MR imaging-magnetoencephalographic study
Author list: Maestu F
Publisher: American Society of Neuroradiology
Publication year: 2003
Volume number: 24
Issue number: 3
Start page: 481
End page: 487
Number of pages: 7
ISSN: 0195-6108
Languages: English-Great Britain (EN-GB)


BACKGROUND AND PURPOSE: Patients with Alzheimer disease (AD) have more
low-frequency activity on conventional EEG and increased focal
magnetoencephalographic (MEG) dipole density (DD) in delta and theta
bands. This activity concurs with atrophy and reduced metabolic and
perfusion rates, particularly in temporoparietal structures. The
relationship between functional and structural measures and their
conjoined capability to improve the diagnosis of AD were assessed in
this study.

METHODS: Whole-head MEG recordings were obtained in 15 patients in
whom the diagnosis of AD had been made and in 16 healthy control
subjects during a resting condition. MR imaging volumetric data were
also obtained; these included global cerebral, temporal lobe, and
hippocampal volumes.

RESULTS: DD in the delta and theta bands was enhanced in the AD
group compared with the healthy control subjects. Slow-wave activity
differed significantly between the groups in the temporoparietal regions
of both hemispheres. Left hippocampal volume was correlated with left
temporal and parietal delta DD and left temporal theta DD. A combination
of left hippocampal volume and left temporal theta DD enabled correct
classification in 87.1% of the patients with AD or control subjects.

CONCLUSION: Results support the predominant role of temporoparietal
hypofunction as defined by DD and hippocampal structural deficits shown
on MR images in patients with AD. A multidisciplinary perspective of
different techniques may improve our understanding of the disease and
our diagnostic abilities.


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Last updated on 2019-10-08 at 00:15