Dysfunctional and compensatory duality in mild cognitive impairment during a continuous recognition memory task

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Publication Details

Author list: Maestu F
Publisher: Elsevier
Publication year: 2013
Volume number: 87
Issue number: 1
Start page: 95
End page: 102
Number of pages: 8
ISSN: 0167-8760
Languages: English-Great Britain (EN-GB)


Abstract

One of the current issues of debate in the study of mild cognitive
impairment (MCI) is deviations of oscillatory brain responses from
normal brain states and its dynamics. This work aims to characterize the
differences of power in brain oscillations during the execution of a
recognition memory task in MCI subjects in comparison with elderly
controls. Magnetoencephalographic (MEG) signals were recorded during a
continuous recognition memory task performance. Oscillatory brain
activity during the recognition phase of the task was analyzed by
wavelet transform in the source space by means of minimum norm
algorithm. Both groups obtained a 77% hit ratio. In comparison with
healthy controls, MCI subjects showed increased theta (p<0.001),
lower beta reduction (p<0.001) and decreased alpha and gamma power
(p<0.002 and p<0.001 respectively) in frontal, temporal and
parietal areas during early and late latencies. Our results point
towards a dual pattern of activity (increase and decrease) which is
indicative of MCI and specific to certain time windows, frequency bands
and brain regions. These results could represent two neurophysiological
sides of MCI. Characterizing these opposing processes may contribute to
the understanding of the disorder.


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Last updated on 2019-13-08 at 00:45