Magnetoencephalographic parietal delta dipole density in mild cognitive impairment

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Subtitle: Preliminary results of a method to estimate the risk of developing Alzheimer disease
Author list: Maestu F
Publisher: AMA American Medical Association
Publication year: 2006
Volume number: 63
Issue number: 3
Start page: 427
End page: 430
Number of pages: 4
ISSN: 0003-9942
Languages: English-Great Britain (EN-GB)


Background: Subjects with mild cognitive impairmerit (MCI) are at a
higher risk of experiencing Alzheiitter disease (AD).
Magnetoencephalographic ternporoparietal dipole densities of
low-frequency activity aregood predictors of individuals'cognitive
status, and might be a Useful tool to investigate the conversion from
MCI to AD.

Objective: To investigate the role of low-frequency dipole densities as predictors of the risk of developing AD.

Design: Whole-head magnetoenceplialographic recordings were obtained
from 1.9 probable AD patients, 1.7 MCI patients, and 1.7 health),
control subjects. The generators of focal magnetic slow waves were
located Using a single moving dipole model.

Results: Left parietal 8 dipole density permitted a reliable
classification of AD and MCI patients. The MCI patients were divided
into 2 groups based on the median left parietal 8 dipole density, and
were followed up for 2 years. The estimated relative risk of conversion
to AD was increased by 350% in those MCI patients With high left
parietal 8 dipole density scores.

Conclusions: Results confirmed the important role of parietal 8
dipole density in the evaluation of AD and MCI. A
magnetoencephalographic-based assessment of AD and MCI patients might be
considered a useful clinical test in the near future.


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Last updated on 2019-13-08 at 00:16