Magnetoencephalographic pattern of epileptiform activity in children with early-onset autism spectrum disorders

Journal article


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Publication Details

Author list: Maestu F
Publisher: Elsevier: 12 months
Publication year: 2008
Volume number: 119
Issue number: 3
Start page: 626
End page: 634
Number of pages: 9
ISSN: 1388-2457
Languages: English-Great Britain (EN-GB)


Objective: To provide further data around magnetoencephalographic (MEG) findings in early-onset autism spectrum disorders (ASD).

Methods: Thirty-six children (mean age 7 years) diagnosed of PDD
(DSM-IV, ICD-10) were studied. There were 22 children with autistic
disorder, 9 with Asperger's syndrome.. and 5 with pervasive
developmental disorder not otherwise specified (PDD-NOS). According to
the Childhood Autism Rating Scale (CARS), the autistic disorder was mild
to moderate in 11, and severe in 11. Neuroimaging studies using
three-dimensional MRI as well as simultaneous MEG-EEG and fusion
techniques through magnetic source imaging (MSI) were performed, with
the aid of anesthesia in non-cooperative patients.

Results: Most patients had no EEG abnormalities. All ASD children
showed common specific abnormalities in the shape of low amplitude
monophasic and biphasic spikes (isolated or short bursts) as well as
acute waves, predominantly distributed in the perisylvian areas. In
Asperger's syndrome, epileptiform spikes were mostly found in the right
hemisphere. No lateralized epileptiform activity was observed in
non-Asperger's autistic patients.

Conclusions: MEG epileptiform activity is frequently documented in children with early-onset ASD.

Significance: Subclinical epileptiform activity is present especially in the perisylvian regions for many patients with ASD.


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Last updated on 2019-13-08 at 00:45