Magnetoencephalographic study in patients with cognitive impairment

Journal article


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Publication Details

Author list: Maestu F
Publisher: Cesar Viguera
Publication year: 2003
Journal: Revista de Neurologia (0210-0010)
Volume number: 36
Issue number: 4
Start page: 307
End page: 310
Number of pages: 4
ISSN: 0210-0010
Languages: English-Great Britain (EN-GB)


Introduction. In early stages, dementia is a neurodegenerative process
with difficult diagnosis. Although well defined clinically, its
neurophysiological, neuroradiological and metabolic diagnosis is still
unsuccessful. Patients and method. A MEG study using a 148- channel
whole-head magnetometer (Magnes 2500 WH) and evaluation by mini mental
state examination (MMSE) was performed in 31 subjects. Statistical
analyses was made to correlate number of dipoles of slow waves and
neuropsychological variables. Results. The 63.3% (21 patients) show slow
waves dipoles in temporal lobes (52.3% were bitemporal). Right temporal
lobe has 119.5 +/- 23.3 dipoles (averaged value), and left temporal
lobe has 1262 +/- 19.8 dipoles (averaged value). The 25% (8 patients)
shown slow waves dipoles in parietals lobes, 5 of them biparietal.
Correlation between MMSE averaged scores and temporal lobe dipoles was
r= -0.84. Conclusion. MEG results show that slow waves dipoles number in
temporal lobes is related with low scores in the mini mental state
examination. MEG could be a usefully complementary method in evaluation
and following of degree of cognitive impairment in these patients.


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Last updated on 2019-10-08 at 00:15