Medial temporal lobe neuromagnetic hypoactivation and risk for developing cognitive decline in elderly population

Journal article


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Publication Details

Subtitle: A 2-year follow-up study
Author list: Maestu F
Publisher: Elsevier: 12 months
Publication year: 2006
Volume number: 27
Issue number: 1
Start page: 32
End page: 37
Number of pages: 6
ISSN: 0197-4580
Languages: English-Great Britain (EN-GB)


Cognition declines as a function of age. However, some elders could
develop more severe status such as mild cognitive impairment (MCI). The
aim of this study was the early detection of neurophysiological patterns
of brain activity that may predict the possibility of certain subjects
to develop MCI. Brain magnetic activity was recorded from 15 healthy
subjects during a memory task by means of magnetoencephalography. None
of the participants could be considered as MCI at the time of the first
clinical evaluation. After 2-year follow-up, five subjects developed MCI
and 10 maintained their cognitive status across time. The subjects who
developed cognitive decline showed a lower number of activity sources in
the left medial temporal lobe between 400 and 800 ms after stimulus
onset, as compared to the non-cognitive decline group. These findings
may help with the early identification of elderly subjects at high risk
of cognitive decline, allowing the possibility of neuropsychological or
pharmaceutical treatment that delay or prevent the progression of the
cognitive impairment.


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Last updated on 2019-13-08 at 00:45