Quantitative magnetoencephalography of spontaneous brain activity in Alzheimer disease

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Sous-titre: An exhaustive frequency analysis
Liste des auteurs: Maestu F
Editeur: Lippincott, Williams & Wilkins
Année de publication: 2006
Numéro du volume: 20
Numéro de publication: 3
Page d'accueil: 153
Dernière page: 159
Nombre de pages: 7
ISSN: 0893-0341
Languages: Anglais-Royaume-Uni (EN-GB)


Quantitative magnetoencephalography (qMEG) was used to investigate
differences in the 2 to 60 Hz spectral power, between Alzheimer disease
(AD) patients and control subjects. Twenty-two AD patients and 21
age-matched control subjects participated in this study. MEG signal
analysis comprised the division of the entire 2 to 60 Hz spectrum in 2
Hz-width subbands. Both the relative power and the contribution of each
subband to the correct classification of AD patients and controls were
calculated. The relative power in 2 bands comprised between 2 to 4 Hz
and 16 to 28 Hz was selected by a restrictive multiple-comparison test..
among the entire 2 to 60 Hz spectrum. Using 2 to 4 Hz values it is
possible to choose a classification rule with an estimate sensitivity
and specificity given by 68% and 76% respectively. Alternatively.. when
16 to 28 Hz values are used, it is possible to obtain a better
classification rule with an estimate sensitivity and specificity given
by 81% and 80%, respectively. To the best of our knowledge.. this is the
first electroencephalography or MEG study where a so exhaustive
analysis of the magnetoelectric spectrum has been performed. This study
supports the notion that more attention should be devoted to the study
of beta band in AD.


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