Reorganization of functional connectivity as a correlate of cognitive recovery in acquired brain injury

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Publication Details

Author list: Maestu F
Publisher: Oxford University Press (OUP): Policy B - Oxford Open Option B
Publication year: 2010
Journal: Brain (0006-8950)
Volume number: 133
Start page: 2365
End page: 2381
Number of pages: 17
ISSN: 0006-8950
Languages: English-Great Britain (EN-GB)


Abstract

Cognitive processes require a functional interaction between specialized
multiple, local and remote brain regions. Although these interactions
can be strongly altered by an acquired brain injury, brain plasticity
allows network reorganization to be principally responsible for
recovery. The present work evaluates the impact of brain injury on
functional connectivity patterns. Networks were calculated from
resting-state magnetoencephalographic recordings from 15 brain injured
patients and 14 healthy controls by means of wavelet coherence in
standard frequency bands. We compared the parameters defining the
network, such as number and strength of interactions as well as their
topology, in controls and patients for two conditions: following a
traumatic brain injury and after a rehabilitation treatment. A loss of
delta- and theta-based connectivity and conversely an increase in alpha-
and beta-band-based connectivity were found. Furthermore, connectivity
parameters approached controls in all frequency bands, especially in
slow-wave bands. A correlation between network reorganization and
cognitive recovery was found: the reduction of delta-band-based
connections and the increment of those based on alpha band correlated
with Verbal Fluency scores, as well as Perceptual Organization and
Working Memory Indexes, respectively. Additionally, changes in
connectivity values based on theta and beta bands correlated with the
Patient Competency Rating Scale. The current study provides new evidence
of the neurophysiological mechanisms underlying neuronal plasticity
processes after brain injury, and suggests that these changes are
related with observed changes at the behavioural level.


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Last updated on 2019-13-08 at 00:45