Spatio-temporal patterns of brain magnetic activity during a memory task in Alzheimer's disease

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Publication Details

Author list: Maestu F, Fernandez, A, Simos, PG, Gil-Gregorio, P, Amo, Rodriguez, R, Arrazola, J, Ortiz
Publisher: Lippincott, Williams & Wilkins
Publication year: 2001
Volume number: 12
Issue number: 18
Start page: 3917
End page: 3922
Number of pages: 6
ISSN: 0959-4965
Languages: English-Great Britain (EN-GB)


Abstract

The brain magnetic activity patterns in a high load probe-letter
(targets and distractors) memory task were examined in patients with
Alzheimers's disease (AD) and elderly controls. Control subjects showed a
higher number of activity sources over the temporal and parietal cortex
between 400 and 700 ms after stimulus onset. However, AD patients
showed a higher number of sources over the frontal motor areas,
including Broca's and the insula. The number of activity sources on the
left parietal areas in response to the target stimuli predicted the AD
score oncognitive (MMSE, CAMCOG) and functional staging (FAST) scales.
These results suggest that a high information load reveals a deficient
functioning of phonological store and reduced task-related activity in
temporal and parietal areas, manifesting in a rapid information trace
decay. The increased, levels of activity in motor areas may reflect a
compensatory strategy in an attempt to facilitate rehearsal speed.


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Last updated on 2019-13-08 at 00:45