Brain morphology and neurological soft signs in adolescents with first-episode psychosis

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Details zur Publikation

Autorenliste: Bombin I
Verlag: Cambridge University Press (CUP): STM Journals
Jahr der Veröffentlichung: 2009
Bandnummer: 195
Heftnummer: 3
Erste Seite: 227
Letzte Seite: 233
Seitenumfang: 7
ISSN: 0007-1250
Sprachen: Englisch-Vereinigtes Königreich (EN-GB)


Beschreibung

Background: Adolescents with first-episode psychosis have increased
severity of neurological soft signs when compared with controls, but it
is unclear whether increased severity of neurological soft signs is an
expression of specific structural brain deficits. Aims: To examine
whether increased severity of neurological soft signs was associated
with decreased brain volumes in adolescents with first-episode
psychosis. Method: Brain scans were obtained for 70 adolescents (less
than 18 years of age) with first-episode psychosis (duration of positive
symptoms less than 6 months). Volumes were assessed using voxel-based
morphometry and through segmentation of anatomical structures. Results:
Increased severity of sensory integration neurological soft signs
correlated with smaller right and left thalamus volume, whereas
increased severity of sequencing of complex motor acts neurological soft
signs correlated with smaller right caudate volume. Conclusions:
Neurological soft signs may be an easy-to-assess marker of
region-specific structural brain deficits in adolescents with
first-episode psychosis.


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Zuletzt aktualisiert 2019-13-08 um 00:45